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Almost 1. 00% of patients cured of blood cancer in trial. Doctors are reporting unprecedented success from a new cell and gene therapy for multiple myeloma, a blood cancer that's on the rise. Although it's early and the study is small - 3. In a second study of nearly two dozen patients, everyone above a certain dose responded. Experts at an American Society of Clinical Oncology conference in Chicago, where the results were announced Monday, say it's a first for multiple myeloma and rare for any cancer treatment to have such success. Speaking at an American Society of Clinical Oncology meet in Chicago on Monday, experts said it's a first for multiple myeloma and rare for any cancer treatment to have such success. WHAT IS MULTIPLE MYELOMA? Multiple myeloma is a type of blood cancer related to leukemia and lymphoma.

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It is formed by malignant plasma cells - white blood cells - in the bone marrow. In healthy people, plasma cells make antibodies that fight infections. In people with multiple myeloma, too much protein is released into the blood and bones. Gradually, it causes organ damage. It can also cause brittle bones, since the malignant cells crowd certain parts of the bone, and dissolve other parts. Bruising is also common, due to a low red blood cell count.

People with highest risk: Over- 6. African Americans. Those with a family history.

Symptoms: Bone pain. Fatigue. Weight loss. Red flags that lead to a diagnosis: Kidney problems. High protein levels. Anemia. Too much calcium in the blood. Chemotherapy helps 1. Dr. Len Lichtenfeld, deputy chief medical officer of the American Cancer Society.'These are impressive results' but time will tell if they last, he said. Multiple myeloma affects plasma cells, which make antibodies to fight infection.

More than 3. 0,0. United States, and more than 1. It's the second fastest growing cancer for men and the third for women, rising 2 to 3 percent per year, according to the National Cancer Institute. About 6. 0,0. 00 to 7. Americans have it now. Nine new drugs have been approved for it since 2.

U. S. patients live five years after diagnosis. With cell therapy, 'I can't say we may get a cure but at least we bring hope of that possibility,' said Dr. Frank Fan. He is chief scientific officer of Nanjing Legend Biotech, a Chinese company that tested the treatment with doctors at Xi'an Jiaotong University. The treatment, called CAR- T therapy , involves filtering a patient's blood to remove immune system soldiers called T cells. These are altered in a lab to contain a gene that targets cancer and then given back to the patient intravenously.

Doctors call it a 'living drug'- a one- time treatment to permanently alter cells that multiply in the body into an army to fight cancer. It's shown promise against some leukemias and lymphomas, but this is a new type being tried for multiple myeloma, in patients whose cancer worsened despite many other treatments. In the Chinese study, 1. The other five had at least a partial remission, with their cancer greatly diminished. Some are more than a year past treatment with no sign of disease. Most patients had a group of side effects common with this treatment, including fever, low blood pressure and trouble breathing. Conversations With Other Women Full Movie.

Only two cases were severe and all were treatable and temporary, doctors said. The second study was done in the U. S. by Bluebird Bio and Celgene, using a cell treatment developed by the National Cancer Institute. It tested four different dose levels of cells in a total of 2.

Eighteen are long enough from treatment to judge effectiveness, and all 1. Maigret 1991 Tv Series. Four have reached full remission so far, and some are more than a year past treatment. The results are 'very remarkable' not just for how many responded but how well, said Dr. Kenneth Anderson of Dana- Farber Cancer Institute in Boston.'We need to be looking for how long these cells persist' and keep the cancer under control, he said. Dr. Carl June, a University of Pennsylvania researcher who received the conference's top science award for his early work on CAR- T therapy, said 'it's very rare' to see everyone respond to a treatment. His lab also had this happen - all 2. CAR- T for leukemia responded, his colleagues reported at the conference.'The first patients we treated in 2.

June said. Dr. Michael Sabel of the University of Michigan called the treatment 'revolutionary.''This is really the epitome of personalized medicine,' extending immune therapy to more types of patients, he said. Legend Biotech plans to continue the study in up to 1. China and plans a study in the U. S. early next year. The treatment is expected to cost $2. Watch Season 4 Wentworth here. Fan said.'The manufacturing process is very expensive and you can't scale up. It's individualized. You cannot make a batch' as is done with a drug, he said.

Nick Leschly, Bluebird's chief executive, said the next phase of his company's study will test what seems the ideal dose in 2.